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The study found that mental decline was less in those who received thiamine. Keith M, Quach S, Ahmed M, et al. Because thiamin dissolves in water, a significant amount of the vitamin is lost when cooking water is thrown out [3]. Int J Clin Pharmacol Ther. *. 2019;54:609-614. doi:10.1093/alcalc/agy091, Katta N, Balla S, Alpert MA. These B vitamins, often referred to as B-complex vitamins, also help the body metabolize fats and protein. Levels of thiamin in the blood are not reliable indicators of thiamin status. FDA does not require food labels to list thiamin content unless thiamin has been added to the food. J Nutr Sci Vitaminol (Tokyo) 1987;33:421-30. For that reason, it's difficult to know how much of a role low levels play in contributing to heart failure. Because of the lack of reports of adverse effects from high thiamin intakes (50 mg/day or more) from food or supplements, the FNB did not establish ULs for thiamin [7]. 2020;34:391-403. doi:10.1097/QAD.0000000000002428, Popa I, Rdulescu I, Drgoi AM, Trifu S, Cristea MB. 2022;70:102853. doi:10.1016/j.ctim.2022.102853. It is also associated with HIV/AIDS, drug dependency, digestive diseases, and certain types of blood cancer. There is no store; thiamin reserves are present as coenzymes; thiamin diphosphate for energy metabolism and redox stability and the triphosphate for nerve transmission. It's not clear yet how thiamine may have an effect on diabetes. Meador K, Loring D, Nichols M, Zamrini E, Rivner M, Posas H, et al. The main role of carbohydrates is to provide energy for the body, especially the brain and nervous system. Int J Mol Sci. Pediatr Clin North Am 2009;56:1105-21. Ask ODS Page GL, Laight D, Cummings MH. Halal is an Arabic word means lawful or permitted. Please review this supplement label with your healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Possible reasons include low dietary intakes, a combination of chronic diseases, concomitant use of multiple medications, and low absorption of thiamin as a natural result of aging [24,25]. Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction. (e.g. Other health problems, such as diabetes, may worsen the condition. The remaining dietary thiamin is in free (absorbable) form [1,2]. Dinicolantonio JJ, Lavie CJ, Niazi AK, O'Keefe JH, Hu T. Effects of thiamine on cardiac function in patients with systolic heart failure: systematic review and metaanalysis of randomized, double-blind, placebo-controlled trials. Institute of Medicine. Explanations for this association include older age, comorbidities, insufficient dietary intake, treatment with diuretics, and frequent hospitalizations [48]. They leave the body through the urine. Does long-term furosemide therapy cause thiamine deficiency in patients with heart failure? Supplements containing B-complex vitamins (including thiamin) or thiamin only are also available. Vitamin A: If source are plant and synthetic, it is halal. Thiamin status is often measured indirectly by assaying the activity of the transketolase enzyme, which depends on TDP, in erythrocyte hemolysates in the presence and absence of added TDP [3]. Thiamin deficiency can cause loss of weight and appetite, confusion, memory loss, muscle weakness, and heart problems. Thiamine is required by our . Kondo K, Fujiwara M, Murase M, Kodera Y, Akiyama S, Ito K, et al. 2021;170(1):13-17. doi:10.1016/j.surg.2021.02.002. Rapidly progressive polyneuropathy due to dry beriberi in a man: a case report. Overview of Wernicke-Korsakoff Syndrome or Alcohol Dementia, The 7 Best B12 Supplements of 2023, According to a Dietitian, Thiamin fact sheet for health professionals, Evaluation of the safety of 500 mg intravenous push thiamine at a tertiary academic medical center, Thiamine for prevention and treatment of Wernicke-Korsakoff syndrome in people who abuse alcohol, Thiamine level in type I and type II diabetes mellitus patients: a comparative study focusing on hematological and biochemical evaluations. For example, thiamin deficiency produces oxidative stress in neurons, death of neurons, loss of memory, plaque formation, and changes in glucose metabolismall markers of Alzheimers disease. At the same time, you will also be able to find another related term in Islamic food, mushbooh which means doubtful or suspect as it is unclear whether they are Halal or Haraam. [, Rabbani N, Alam SS, Riaz S, Larkin JR, Akhtar MW, Shafi T, et al. Most dietary thiamin is in phosphorylated forms, and intestinal phosphatases hydrolyze them to free thiamin before the vitamin is absorbed [1]. [, Rodriguez-Martin JL, Qizilbash N, Lopez-Arrieta JM. Hi do you guys have info on these: When thiamine levels get too low, it may initially cause signs and symptoms such as: A more severe or long-term thiamine deficiency may cause complications, including conditions called beriberi and Wernicke-Korsakoff syndrome. J Alzheimers Dis. A more common manifestation of thiamin deficiency in the United States is Wernicke-Korsakoff syndrome [2]. As a vitamin, Nicotinic acid/Niacin is general recognized as halal. [1] Only small amounts are stored in the liver, so a daily intake of thiamin-rich foods is needed. To come to this conclusion, we looked at the ingredient list of Chocolate Oreos and here's what we found: Sugar; Unbleached Enriched Flour (Wheat Flour, Niacin, Reduced Iron) Thiamine Mononitrate (Vitamin B1) Riboflavin (Vitamin B2), Folic Acid) For adults, excretion of less than 100 mcg/day thiamin in urine suggests insufficient thiamin intake, and less than 40 mcg/day indicates an extremely low intake [6]. The recommended daily allowance (RDA) of thiamine can vary by age and pregnancy status as follows, in milligrams (mg), which can be obtained through food sources or oral supplements: Note that Verywell Health prefers to use inclusive terminology, but when citing health authorities or studies, the terms relating to sex and gender from those sources are used. Ann N Y Acad Sci. This vitamin plays a critical role in energy metabolism and, therefore, in the growth, development, and function of cells [1]. Fresh or dried fruits. The three studies randomly assigned fewer than 20 patients each, and the two crossover studies did not include a washout period [55-57]. Some foods (bread, cereals, and infant formula) are fortified with thiamine to ensure most people receive enough in their diet. You may do the same if you notice an error in our list or want to know why the particular ingredient is halal, haram or doubtful. Prog Cardiovasc Dis. [, Gibson GE, Sheu KF, Blass JP, Baker A, Carlson KC, Harding B, et al. Thiamine is obtained from the diet. Hashimoto's Disease-Related Fatigue and Thiamine Levels, Beriberi as a Result of Thiamine (Vitamin B1) Deficiency, Taking on Vitamin Deficiencies in Hepatitis C, Guide to Dietary Supplements and Thyroid Disease. Thiamine may also help in preventing the cardiovascular complications associated with diabetes. Treatment is with thiamine supplementation. In: Coates PM, Betz JM, Blackman MR, et al., eds. We can get the recommended amounts of thiamin by eating a variety of foods. Thiamine, also called vitamin B1, is a water-soluble vitamin found in virtually every cell in the body. A thiamine deficiency may occur when people are either not getting enough thiamine from their diet or they are not absorbing it properly. Washington, DC: National Academy Press; 1998. It is Halal if it is made from plant sources or if it is Halal or Kosher certified. Thiamine is vitamin B1, of which there are several different types that are used as supplements. Thiamine, or vitamin B1, is a water-soluble vitamin that is found in some foods and may also be taken as a supplement. Cochrane Database Syst Rev. Aguilar F, Charrondiere UR, Dusemund B, Galtier P, Gilbert J, Gott DM, et al. How Do I Know If I Have a Thiamine Deficiency? About half of the thiamin in the U.S. diet comes from foods that naturally contain thiamin; the remainder comes from foods to which thiamin has been added [9]. However, some cases of this syndrome become so severe that people develop chronic (long-term) health problems, especially with memory. A deficiency of thiamine, or vitamin B1, may go undiagnosed and is associated with poor health outcomes, including death. Jpn J Clin Oncol 1996;26:234-6. In adults aged 20 and older, the average daily thiamin intake from foods is 1.95 mg in men and 1.39 mg in women. Should people with diabetes take a thiamine supplement? However, even if supplements are third-party tested, it doesnt mean they are necessarily safe for all or effective in general. It is also known as vitamin B1. Individuals taking these and other medications on a regular basis should discuss their thiamin status with their health care providers. Fresh or naturally frozen vegetables. At this chronic state of the disorder, parenteral thiamin treatment does not lead to recovery in about one-quarter of patients [22]. Thiamine deficiency in patients with congestive heart failure receiving long-term furosemide therapy: a pilot study. DiNicolantonio JJ, Niazi AK, Lavie CJ, O'Keefe JH, Ventura HO. A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy. J Endocrinol Invest 2012;35:951-6. Diab Vasc Dis Res 2006;3:120-1. The natural history and pathophysiology of Wernicke's Encephalopathy and Korsakoff's Psychosis. American Society for Metabolic and Bariatric Surgery integrated health nutritional guidelines for the surgical weight loss patient 2016 update: micronutrients. [. One of these studies found that 13% of 150 patients with cognitive impairment and acute-onset behavioral disturbances were considered thiamin deficient based on plasma levels [26]. Elizabeth Barnes, RDN, is a registered dietitian nutritionist who specializes in eating disorders, type 2 diabetes, and heart health. [, Vognar L, Stoukides J. American Society for Metabolic and Bariatric Surgery. Therefore, this article makes it easier for you to find out if an ingredient is halal or . The Royal College of Physicians report on alcohol: guidelines for managing Wernicke's encephalopathy in the accident and Emergency Department. The relevance of these effects to clinical prognosis or outcomes is not known. The different rates of thiamin deficiency in patients with heart failure in these and other studies are probably due to differences in nutrition status, comorbidities, medications and dietary supplements used, and techniques used to measure thiamin status [48]. Xu M, Ji J, Lu Q, Gong J, Luo Z, Zhu L. The effects of thiamine supplementation on patients with heart failure: a systematic review and meta-analysis of randomized controlled trials. It's made with high-quality ingredients and all the essential vitamins and minerals to keep your heart +, brain, and eyes healthy and protected. Vanillin: Flavoring agent, extracted from vanilla. TDP serves as an essential cofactor for five enzymes involved in glucose, amino acid, and lipid metabolism [1,3]. Can i have a friend who is a girl for the sake of Allah, How to Make Hand Sanitizer With Natural Ingredients, 10 Islamic Guidelines on Pandemics and Epidemics, Arabic Dua for Travelling With English Translation, How to Protect Yourself from the Corona Virus. Thiamine helps some of the enzymes in the body that are used in the metabolism of glucose. Thiamin also plays a role in muscle contraction and conduction of nerve signals. It is also not stored by the body, so a steady supply is needed. The body needs thiamine to keep blood glucose levels steady, so this can lead to complications in people with diabetes. Korsakoff syndrome: an overlook (review). National Institutes of Health Office of Dietary Supplements. Helps promote heart health+, supports normal brain function, and maintains healthy eyes in older adults. Amber J. Tresca is a freelance writer and speaker who covers digestive conditions, including IBD. J Nutr Sci Vitaminol (Tokyo) 2012;58:210-6. The U.S. Department of Agricultures (USDAs) FoodData Central website [10] lists the nutrient content of many foods and provides a comprehensive list of foods containing thiamin arranged by nutrient content and by food name. By Amber J. Tresca For healthy adults in the United States, a balanced diet usually provides enough thiamine. It is naturally present in whole grains, meat (especially pork), and fish. Pls also merits of islamic month. This is because people in developing areas may not get enough thiamine in their diet. Thiamine (vitamin B1) is used to prevent or treat low levels of vitamin B1 in people who do not get enough of the vitamin from their diets. Thiamin is naturally present in some foods, added to some food products, and available as a dietary supplement. People who arent able to eat enough food with thiamine in it, such as those who are receiving nutritional support because of an illness, may not be getting enough of this vitamin. The amount of thiamin recommended during pregnancy and lactation varies depending on the pregnancy's phase and the energy needs of the person. Chocolate Oreo is Halal due to the ingredient list, but it is not Halal certified in North America. This is a fact sheet intended for health professionals. 2013;11:183. doi:10.1186/1741-7015-11-183, Starling-Soares B, Carrera-Bastos P, Bettendorff L. Role of the synthetic B1 vitamin sulbutiamine on health. It should be discarded after the expiration date on the packaging has passed. Cardiovascular magnetic resonance in wet beriberi. Since most ingredients are listed using their chemical name, its difficult to figure out if they are halal or not. Looks like all are from Vegetables but still wanted to confirm: Vegetable Cellulose, Vegetable Stearic Acid, Contains 2% of: Natural Palm Leaf Glaze, Silica, Vegetable Magnesium Stearate, you can add peprika extract and pepper extract. What do you think? Thank you, {{form.email}}, for signing up. Thiamin is found in fortified processed flours and ready-to-eat cereals, lean pork, beef, wheat germ and whole grains, yeast, organ meats (especially liver), eggs, fish, legumes, and nuts. Allithiamine exerts therapeutic effects on sepsis by modulating metabolic flux during dendritic cell activation. The authors of a systematic literature review and meta-analysis found two randomized, double-blind, placebo-controlled trials of thiamin supplementation in people with heart failure that met their eligibility criteria [50]. Thiamine (Vitamin B1), Biotin (Vitamin B7), Niacin (B3) Vitamin B6 bidrager til normal nervesystem . Overview. A 2008 literature review identified 84 cases of Wernickes encephalopathy after bariatric surgery (primarily gastric bypass surgery) between 1991 and 2008 [35]. Therapeutic potential of vitamin B1 derivative benfotiamine from diabetes to COVID-19. Most people get enough thiamine through their diet. The association between thiamin deficiency and HIV/AIDS is probably due to malnutrition as a result of the catabolic state associated with AIDS. Case Rep Oncol 2010;3:362-7. Body stores are limited, and deficiencies can develop quickly. Thiamine deficiency and delirium. The published literature includes several cases of beriberi or Wernickes encephalopathy resulting from treatment with this drug, possibly because the drug might increase thiamin metabolism and block the formation of TDP, the active form of thiamin [60-63]. Information was obtained from several sources including Muslim Consumers Group, Wikipedia and RoadIslam.com. 2013;7:CD004033. This makes thiamine levels important in diseases of the metabolic and gastrointestinal systems. The following products are definitely Halal: Milk (from cows, sheep, camels, and goats) Honey. *DV = Daily Value. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Apple Cider Vinegar (Halal in USA and Canada, verify in other countries), Artificial Colors or FD&C Yellow No. Groups With a Higher Incidence of Thiamine Deficiency. Some of the studies on diabetes and thiamine have been observational, which means that they are taking information from what people are doing and what their thiamine levels are but not using any kind of intervention. J Am Geriatr Soc 2009;57:2166-8. Thiamine is also available as a supplement and by prescription as an . Foods providing 20% or more of the DV are considered to be high sources of a nutrient, but foods providing lower percentages of the DV also contribute to a healthful diet. O you who have believed, eat from the good things which We have provided for you and be grateful to Allah if it is [indeed] Him that you worship. Surah Baqarah 2:172. Thiamine-dependent processes and treatment strategies in neurodegeneration. The review authors stated that it was not possible to draw any conclusions from these three studies because they were small and the publications describing them did not provide enough detail to combine these data in a meta-analysis. Cochrane Database Syst Rev 2013;7:CD004033. 2021;58(11):1433-1439. doi:10.1007/s00592-021-01752-4, DiNicolantonio JJ, Liu J, O'Keefe JH. Acta Biomed Ateneo Parmense 1992;63:43-9. 2020;2020:9349063. doi:10.1155/2020/9349063. However, the FNB noted that in spite of the lack of reported adverse events, excessive intakes of thiamin could have adverse effects. Because thiamin can only be stored in the body for a short time before it is readily excreted, a regular dietary intake of thiamin is necessary to maintain proper blood levels. Acta Diabetol. Some small studies have found that thiamin levels in plasma are up to 76% lower in people with type 1 diabetes than in healthy volunteers and 50%75% lower in people with type 2 diabetes [31,32]. It is listed as doubtful and I wanted to know if they are listed as vegan are they halal or not because I know some products can be made using alcohol. Ochsner J 2013;13:495-9. 2020;12:e8027. Beriberi is not common in the United States and other . Arch Neurol 1991;48:81-3. Thiamine is considered a form of vitamin B that is water-soluble. Healthy adults, with an average diet of 2000 kcal, should aim for 1 mg of thiamin per day. Limits foods and beverages higher in added sugars, saturated fat, and sodium. Wernicke's encephalopathy: occurrence and pathological aspects in a series of 400 AIDS patients. Thank you for your time. Thiamin (vitamin B1) helps the body's cells change carbohydrates into energy. This disorder is about 810 times more common in people with chronic alcoholism than in the general population, but it can also develop in patients who have severe gastrointestinal disorders, rapidly progressing hematologic malignancies, drug use disorders, or AIDS [2]. Nutr Clin Pract. Taken orally, it's not expected to cause adverse reactions at higher levels, but theres also no data to prove otherwise. Among children and teens, the average daily thiamin intake from foods is 1.27 mg for ages 25 years, 1.54 mg for ages 611 years, and 1.68 mg for ages 1219 years [14]. There are many whole-food and fortified-food sources of thiamine, including: Thiamine (vitamin B1) is often found in multivitamins, usually with other B vitamins. However, another study found no effect of 900 mg/day benfotiamine on urinary excretion of albumin or kidney injury molecule-1, a marker of kidney injury [46]. Wernicke-Korsakoff syndrome is one of the most severe neuropsychiatric sequelae of alcohol abuse [37]. National Institutes of Health Office of Dietary Supplements. Wooley JA. Up to 80% of people with chronic alcoholism develop thiamin deficiency because ethanol reduces gastrointestinal absorption of thiamin, thiamin stores in the liver, and thiamin phosphorylation [3,19]. Diabetes Care 2010;33:1598-601. U.S. Department of Agriculture, Agricultural Research Service. Halal Nicotinic acid/Niacin Nicotinic Acid is a vitamin manufactured through chemical synthesis, available as White Crystalline powder. However, talking with a healthcare provider about dietary supplements is important for those who live with the condition. The recommended daily intake (RDI) for adults over age eighteen is 1.2 mg/day for men and 1.1 mg/day for women. The body excretes excess amounts of thiamin in the urine [2]. Diabetologia 2009;52:208-12. Thiamine is given first by IV for several days and then with an oral supplement, along with several other B vitamins. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. [. Osiezagha K, Ali S, Freeman C, Barker NC, Jabeen S, Maitra S, Olagbemiro Y, Richie W, Bailey RK. A placebo-controlled trial in people with Alzheimer's disease showed that supplementing with a form of thiamine was considered safe. Also called Vitamin B3, Vitamin PP or Niacin, NicotinicAcid is slightly soluble in water, glycerol [] The body uses thiamine to get the energy to grow cells and support body functions. Thiamin is naturally present in some foods, added to some food products, and available as a dietary supplement. The total thiamine pool in the average adult is about 30 mg. An intake of 0.5 mg per 1000 kcal per day . Vitamin B1: As Thiamine (synthetic and from eggs) [, Larsen TR, Dragu D, Williams M. Wernicke's Encephalopathy: An Unusual Consequence of the Acquired Immune Deficiency Syndrome-Case Report and Literature Review. [. Alcohol Alcohol 2002;37:513-21. Thiamin is available in many dietary supplements. Can J Clin Pharmacol 2003;10:184-8. These particular ingredients may or may not have animal derived ingredients or alcohol. Modern Nutrition in Health and Disease. If any symptoms of thiamine levels appear, it's important to talk to a healthcare provider right away. The most commonly used forms of thiamin in supplements are thiamin mononitrate and thiamin hydrochloride, which are stable and water soluble [1,12]. doi:10.1002/14651858.CD004033.pub3, Anwar A, Ahmed Azmi M, Siddiqui JA, et al. 2020;43:964-973. doi:10.14348/molcells.2020.0198, Allowitz KV, Yoo JJ, Taylor JR, et al. Giving the supplement slowly and with fluids may help cut this risk, but there arent any accepted guidelines. Estimated Average Requirement (EAR): Average daily level of intake estimated to meet the requirements of 50% of healthy individuals; usually used to assess the nutrient intakes of groups of people and to plan nutritionally adequate diets for them; can also be used to assess the nutrient intakes of individuals. We require a regular supply of dietary thiamin. Solgar Vitamin B-Complex "50" indeholder 50 mg af hvert vitamin B. Riboflavin (Vitamin B2), Niacin (Vitamin B3), Vitamin B6 og B12 bidrager til at reducere trthed og udmattelse. Foods, fortificants, and supplements: Where do Americans get their nutrients? Polegato BF, Pereira AG, Azevedo PS, et al. Boldorini R, Vago L, Lechi A, Tedeschi F, Trabattoni GR. Role of thiamin in health and disease. [, Butterworth RF, Besnard AM. The average daily thiamin intake from foods and supplements in children and teens is 1.51 mg for ages 25 years, 1.76 mg for ages 611 years, and 1.95 mg for ages 1219 years. Diabetologia 2007;50:2164-70. Eur J Nutr 2011;50:145-9. A case of Wernicke's encephalopathy following fluorouracil-based chemotherapy. In adults aged 20 and older, the average daily thiamin intake from foods and supplements is 4.89 mg in men and 4.90 mg in women. Although beriberi is rare in the United States and other developed countries, people in these countries do occasionally develop the condition [15-18]. An analysis of data from the 2003-2006 National Health and Nutrition Examination Survey showed that only 6% of the U.S. population has a usual intake below the EAR [9]. 2020;78:1015-1029. doi:10.1093/nutrit/nuaa004, Le Berre AP, Fama R, Sassoon SA, et al. [, Aasheim ET. The discovery of thiamin. -Lauric acid Yet it isn't clear that thiamine helps heart failure patients do any better in the long term. Alcohol Alcohol 2009;44:148-54. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications. Thiamin: One of the B complex vitamins. Thiamin supplements might reverse some of these effects. These lower thiamin levels might be due to increases in clearance of thiamin by the kidneys. Vitamins. Severe encephalopathy, lactic acidosis, vegetative instability and neuropathy with 5-Fluorouracil treatment - pyrimidine degradation defect or beriberi? As Muslims, we must have knowledge of halal and haram ingredients in order to eat what is permissible. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Other studies have shown a higher risk of thiamin deficiency in people with type 1 and/or type 2 diabetes based on tests of erythrocyte transketolase activity [33,34]. Food Labeling: Revision of the Nutrition and Supplement Facts Labels. Alcohol use disorder could lead to a lack of thiamine and the development of Wernicke-Korsakoff syndrome. About half of these patients experienced long-lasting neurologic impairments. Vanillin: Flavoring agent, extracted from vanilla. However, the authors recommend parenteral thiamin supplementation for patients at high risk, such as those with ataxia, confusion, and a history of chronic alcohol misuse, because oral supplementation is unlikely to produce adequate blood levels. J Nutr 2011;141:1847-54. Blood thiamine levels in outpatients with diabetes mellitus. 3 The body uses thiamine to get the energy to grow cells and support body functions. Nutritional deficiencies in obesity and after bariatric surgery. Few studies have assessed the prevalence of thiamin deficiency in people with Alzheimers disease. Hi, i just want to know about niacin and thiamin. The federal government's 20202025 Dietary Guidelines for Americans notes that "Because foods provide an array of nutrients and other components that have benefits for health, nutritional needs should be met primarily through foods. Autopsies of 380 people with AIDS found that almost 10% had Wernickes encephalopathy [29], and some experts believe that thiamin deficiency is underdiagnosed in this population [30]. Thiamin is a water-soluble vitamin which is essential for energy metabolism. Amber J. Tresca is a freelance writer and speaker who covers digestive conditions, including IBD. [. Thiamin fact sheet for health professionals. These studies were not successful in determining what the dosage of thiamine should be to reverse the symptoms of this condition or to prevent it. She was diagnosed with ulcerative colitis at age 16. Includes a variety of vegetables; fruits; grains (at least half whole grains); fat-free and low-fat milk, yogurt, and cheese; and oils. Injectable thiamine must be given by a healthcare professional. Metab Brain Dis 1990;5:179-84. Allen L, de Benoist B, Dary O, Hurrell R, eds. The most common effect of thiamin deficiency is beriberi, which is characterized mainly by peripheral neuropathy and wasting [1-3]. Halal Vitamin B1 (Thiamine Hydrochloride and Thiamine Mononitrate) is a type of vitamin manufactured through chemical synthesis. Verywell Health's content is for informational and educational purposes only. Thiamine supplementation for the treatment of heart failure: a review of the literature. Future Med Chem. Incidence of adverse reactions to parenteral thiamine in the treatment of Wernickes encephalopathy, and recommendations.