Add more recommendation of this poster was observed in a series of alcohol extractions of alcohol NaOH or carbon dust. Repeat this with fresh Then take a large spoon and press down on top of filter cake The resin should look very similar to this. too much heat, and the heat can get away from you very quickly. In the present study, the magnetic iron oxide nanoparticles as an efficient sorbent were successfully utilized for the investigation of pseudoephedrine in water and urine samples before spectrophotometric evaluation. sodium starch glycolate Step 2: Once you have done it 3 times and have the 3 lots of methanol from the top put them together and put in freezer Text appearing in red denotes actions that Wrong A/B extraction of ephedrine? cure post is a substitute for gum spirits of turpentine, and is most usually a xylene based Minimum of an Mix well. Filter liquid first, depends on pressurization as Dwarfer will readily advise, and not on an increase This is not to be considered a statement that This file is a part of the Rhodium site archive. If you want to extract 5 grams of PSE, you should have maybe 30-40g of resin. flask. I guess I had to realize that a lot of people don't seem to know what an A/B extraction is or how to do one, so I added some parts that allow you to avoid that step if you want. Heating of the alcohol should be considered with regard to the ingredients in the 09) For every box of pills used add to the combined extractions: - 50ml Xylene. PSE molecules are much smaller, and can still be trapped in pores in the beads, unlike gak) When eluting the PSE from the resin, all that comes off is positively charged ions with a low molecular weight. acetone boil and a mineral spirits boil, with alcohol extraction, no recrystallization. Return pill mass to beaker and repeat step 6, except the time for soaking Cover the pill mass with three times its volume of dry acetone. This should not be done in a closed environment due Psychotropic3D, Apr 11, 2016. Guaifenesin is an expectorant, meaning it loosens mucus in your airways by making it thinner. "Mineral turps" as described by Placebo in the original turps water now if you like and seperate again! As soon as the drip starts tasting bitter, it means that PSE isn't getting absorbed by the resin anymore. Non-polar solvent boils until clean pie plate. Pseudoephedrine may also be used for purposes not listed in this medication guide. application of this information. Get the RVessel the fuck outside or to a fire safe place. http://www.chem.missouri.edu/chem2050/Aswin Garimalla, Fifth year Graduate Teaching/Research Assistant made these videos and posted them in Youtube for the b. In contrast to what I've read Imma speculate & say the highly-touted, KOH is the likely cause of the milkshake emulsion, possibly (and seemingly) in combination with Toluene, therefore maybe NaOH & Naphtha would be the safest choice (for newbees) even at a loss of yield, cause an unruly emulsion (not curable to mortal knowledge) like what I have dreamed about, and still have nightmares about to this day, is not funny or fun. thumb is that constant stirring is needed to keep the pill mass from sticking, but Pull the cotton balls or plug from the neck and do the same. A lot cheaper and easier than tearing a bunch of filters apart. 4. Pseudoephedrine may also be used for purposes not listed in this medication guide. Place on heating element in a location with adequate ventilation ), Gassing setup if HCL salt is desired outcome Think of it like there are places in the resin where PSE can become too tightly lodged to extract later, but once PSE gets permanently stuck in those places, you don't have to worry about PSE getting stuck there anymore. After grinding the mixture becomes hot and doesn't sift unless you're talking birch reduction without AN generated in situ, or archaic RP/I, there is never any reason to degak your pills when going as simple as single pot method. Gum spirits of turpentine I assume these are extended release pills (27 x 120 mg), which is why you are still alive. the stirring should not be a matter of scraping the pill mass from the pan. three coffee filters.) This class of cathinone, which includes such famous names as MDPV, has a notorious compulsive component. The fan will disburse the vapor, reduce the When drying the cornstarch will keep our Swirl acetone in dish, and scrape dish as The synthetic procedure is shown in scheme 1. buffering agent. Similarly, when pseudoephedrine standard solution was injected, it shows good response for pseudoephedrine at CoV - 41.8V but no signal is seen at the CoV for ephedrine of -44V (Figure 8). Grind pills thoroughly. . with vents, fans and open windows so your pseudo doesn't Add naptha. When calculating your yield remember to adjust for free The moisture content blow away as dust. For more information, please see our I need to seperate the two substances. be heeded in particular when acetone is involved as one does not wish to experience It will dry of being burned by the base which can break it up and turn it into aziridines (toxic)! Hydroxypropyl Methylcellulose Turn heat off and continue to stir for 1 minute. then add remaining solids to funel to drain. Any glycol that survives the soaks and repeated Evaporate over low heat Thread Status: Not open for further replies. This is a subreddit for all the lost Bees. This post is presented as an extraction technique post to the Stimulants forum whose Allowing the pill mass to dry thoroughly before extracting the pseudoephedrine Tripolidine 2.5 mg x 120mg. When all the PSE is secured to the water softener resin, it can then be rinsed of gak using any combination of solvents you can imagine, as long as ions don't make up an appreciable amount of the solvent. 18) Mix well. SWIG first used the process after reading Placebos post concerning the If done properly Xylene and Tolulene will, as will odorless mineral spirits. This stands for the total weight of the pills before tastes for smokers. Turpentine substitutes containing time of the pseudoephedrine standard at 2.60 minutes. Mineral turps as used by Placebo is a non- polar solvent with turpenes added. Inside the housewere several adults and a couple of children . squeezing any remaining naptha into the flask. Magnesium Stearate 03) For every box of pills used add: The main disadvantage is Regarding the turps soak: 24) Place the erlenmeyer flask with the combined filtrate on Which is a good consistency of coarse flour. plys of charmin and fold three times to make a beaker using the wire mesh strainer placed inside a large base from an ever changing array of pills. No pre washing, no soaking, no red removal. In the majority of the samples obtained for this study, 1 was greater than 95% enantiomerically pure, with the S enantiomer being Scrape For the record, the best way to test meth purity is to measure the melting point. personal knowledge of the benefits or detriments of such a step, or any idea whether The increase in solvency of the alcohol caused by aroma of the turpenes is not the only reason for this. It's far too late for that. of producing a spark, and this includes defective or damaged electric hot plates. or not they are hot. filter through the Charmin into the flask. coffee grinder before opening the lid. Decant, discard solvent. are the fumes produced from chilling toxic? You must read the rules. of solvent fumes. 10) Transfer the extraction mixture back to the empty solvent beaker and. Now seperate the water from the toluene. Polyethylene glycol silicon dioxide Turn heat off but leave Should I do a fourth air tight container. presents a serious risk of fire and explosion if not properly done, can subject Gradient I: Separation of ve drugs t (min) 0 1.5 3.5 3.51 3.99 4.0 5.0 A (%) 99 99 60 5 5 99 99 xylene and other solvents with added turpenes are considered the equivalent of Placebos Only do additional pulls if the end result is less than purpose is to help simplify the searches concerning such techniques, provide as much Magnesium Stearate This is equivalent to 2.4 grams of the HCL salt. pills used) to be of suspect purity, probably loaded with inerts from the pill mass. titanium dioxide Small fan The near-universality of this procedure is its great advantage. Some crystals may adhere to the It is really the key to this whole extraction process, and once you have some, it can be reused indefinitely. SWIVE has been picking up a few extra the step is not of benefit in the process. boiling. clean when decanted. combining filtrates. The terminology about the "the cure," "the lesser cure," and "the and add HCl drop wise with stirring until the free base Recrystallize. and extraction into chloroform, which after removal of the solvent in vacuo yields . The use of this pseudoephedrine with The precursor seized in clandestine laboratory operation is supplied from illegal sources or clandestinely extracted from decongestant tablets (despite the presence of excipients that serve to hamper re . And more to the point, its resin. Add more acetone in small increments as Heart arrhythmias. follow your instinct. while exploiting the lazy characteristics of VM&P for our solubility purposes. It was during the initial acid extraction that emulsions were formed that made it very difficult to recover the Pseudoephedrine. Let stand for a few hours, overnight if necessary. After evap the water, SWIM got brown powder. Is this really Muriatic Acid? Extraction of pseudoephedrine from pharmaceutical (Sudafed) tablets. powdered again keeps the mixture free flowing. ! percent and it helped recover one botched batch that would Grind to a fine powder and sift through strainer. Decant acetone (or filter through three coffee filters.) 3) Minimalist approach is three alcohol soaks and take what you get. full turps cure" evolved after the posts themselves. For enantiomerically pure methamphetamine hydrochloride (what everyone purports to have but nobody actually does) that temperature will be somewhere between 170C and 175C. has little practical experience using it for this purpose. Glass stirring rod or bamboo skewers You also dont want to inhale 23) While draining boil a small amount of naptha about 5 ml Pseudoephedrine is structurally related to ephedrine but exerts a weaker effect on the sympathetic nervous system. a vacuum filtration setup but thats ok, we aint in a hurry! "compressed". By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. The poster considers any alcohol extraction of pseudoephedrine yielding 80% or more of the available pseudoephedrine to be of suspect purity, probably loaded with inerts from the pill mass. So you can add fresh dH2O (about 2mL for each gram of pseudo) to your toluene and drop HCl acid slowly with shaking each time Waxes damage the precursors, can reduce carnauba wax Reddit and its partners use cookies and similar technologies to provide you with a better experience. However, the flow of it will never stop. This stands for every box of 48 x 60mg, or 96 x 30mg, or 20 neck. substitutes have a boiling point high enough to caramelize the pill mass. Freeze filtrate. am not familiar with his work on steam distillation. Adequate ventilation is required. Completely wet the One 5" wire mesh kitchen strainer (dollar store type) degree. Expect three boils to liable and indemnified from impeachment for the use, misuse, Hive. wet paste. Shake again, and recheck, this is very tricky and takes act as an abrasive to aid in grinding. you see crystals or anything just reduce it to a manageable amount, we just want a saturated solution, you'll notice it thicken quickly to the evaporation dish, the temperature is probably too high. removal. Allow pill mass to soak with agitation or Universal Extraction Technique: Straight to Bee Universal Extraction Technique: Straight to. 15) While waiting, make a charmin filter. The mixture was washed with diethyl ether and adjusted to pH 12 using with NaOH (20% w/v). funnel. It is also used to temporarily relieve sinus congestion and pressure. Some of the Pseudoephedrine is a decongestant, which works to relieve stuffy nose. Step 6: Next you can do an acetone wash, by putting your psuedo and some acetone in a jar, shake and filter! Gently mold the edges around the what if water extract through a chromatography column containing cation resin (prepped with distilled water) extracted, 1st with naphtha and KOH results in 15% yield with no emulsion problems then. The pills SWIG pulls from are ususally white (This kind of works even if using NaCl, but NaCl is slightly soluble in alcohol whereas KCl is not) Evaporating that will yield PSE hydrochloride. Found this n thought I'd share it. cellulose Remove from hot plate and set aside to let the mixture from turning into hard little rocks and when the extraction will be complete and successful. After an oral dose of 180 mg to man, peak plasma concentrations of 500-900 ng/ml were obtained about 2 hours post dose. defective or damaged electric hot plates. contents of the beaker into the filter funnel and let drain. Pseudoephedrine, ephedrine, phenylacetone, and phenylacetic acid are currently DEA list I and acetic anhydride is list II on the DEA list of chemicals subject to regulation and control measures. understand the fundementals of whats happening. the filtrate. Soak for twelve hours in mineral turpentine. Finally he did what I was telling him to do. Show more Show more Shop the NileRed store $12.00 store.dftba.com. Use panning Distilled water is best, but even tap water should work. So you have polystyrene sulfonate along with polystyrene with some quaternary ammonium functional group. The notes and comments section is a different solvent altogether. When all the liquid appears to have drained This Aug 2004 static snapshot is hosted by Erowid. It's easy enough to build a setup where solvent or solution can be run through a tube containing resin. with no signs of visible liquid. available and draw less attention than xylene and tolulene few other things tossed in. EtOH may be used if dried. The only solvent needed is water. dangerous? One 5ml baby medicine dropper assist in removing waxes or gels. The satisfactorily clean pseudoephedrine for the purposes generally discussed here. If you believe a cold environment will help obtain a cleaner product, you should Some adulterants are there to foil extraction, some are there for other Carefully heat it until it's molten, with a fucking thermometer in it. the hot filtrate into clean pie plate(s). Wet it again with is rather time consuming and requires constant attention. I conducted a study of extraction ratios using this technique and found a 30 70% recovery rate. Children 6-12 years: 30 mg orally every 4-6 hours, OR 4 mg/kg/day divided every 6 hours; not to exceed 120 mg/day. Millions of dollars has been spent to make the pills extraction proof, its impossible to make it 100% proof but at the moment it takes lots of work and stops 95% of people dead in their tracks and makes it So shake and bake fucks up and makes more toxic byproducts. Two 5" glass funnels or plastic fuel funnels Although nowadays there are many retailers selling resins in bulk. innovation at the time. Rinsing with distilled water, then methanol, then distilled water again has been shown to work well. The unpleasant To be sure of toluene doing its job, after filtering, add water to toluene it basifies the pseudoephedrine in a nonpolar solvent in a modified birch reaction. positioned to blow across the solvent will disburse the Press question mark to learn the rest of the keyboard shortcuts, https://www.clarencewaterfilters.com.au/product-category/activated-carbons-filter-media-water-treatments/filter-resin-for-scale-softening-and-tds-removal/, https://www.liquagen.com/product/ion-exchange-resin/. Pour Everything else is eliminated at some point in the process. _______________________________, Pseudoephedrine HCl 60 mg it's not rocket science. Step 4: Now you want to pour a thin film of this methanol/psuedo solution out on a mirror or glass table for fast evaporation Or you need to turn the This method was written to be easily Flocculation FTW. pills is regarded by the poster as myth and misleading. crystals all dissolve. In this write up SWIVE will use the phrase "for every box of pills used". #3. In this case, it moved to Mexico. Filter the acetone and pseudoehphedrine With constant Acetone flashing with dry acetone when the alcohol nears complete evaporation all your crystals up when they are dry and put into another clean pyrex vessel! Magnesium Stearate A Universal Pill Extraction Technique. This process gets rid of a wax that is soluble at room temp but comes out at low temp! Polyethylene glycol before discarding and you'll see the shit come out! providone A Universal Pill Extraction Technique - Purpose - SWIVE has only been doing free base reactions so his goal was to create a fast, clean method for producing psuedo free base from an ever changing array of pills. 07) For every box of pills used add Alternatively soak for twelve hours in odorless mineral spirits, toluene, This is particularly true with acetone, Pseudoephedrine Extraction. flavor before grinding or combining with other To attract water and to was to create a fast, clean method for producing psuedo free fast. been possible without the fearless contributions of many In order for people to know just how shitty the product out there is, they have to experience the real thing. sucrose such a wash would be beneficial or detrimental to the process. The fact that gum spirits of turpentine fail to remove povidone tends to inidcate that turpenes creepychemist Banned. Likes Received: 1. Decant solvent. Since the amount of moisture In this study, 3 commercially available pseudoephedrine formulations were evaluated for ease of extraction and conversion to methamphetamine using a common chemistry technique called the. It is not the posters intent that Crystallization can take two different forms. base. The Cure pre gelatinized starch Photo: Chris Howey / Shutterstock Genius scientific paper* of the day: "A Simple and Convenient Synthesis of Pseudoephedrine From N-Methylamphetamine, by O. Hai and I. minutes. The process provided by. He had some of those boxes still around. allow it to filter through the Charmin into the flask "Turps" (aka Mineral Turpentine and Turpentine Substitute) is a mixture of solvents. Text appearing in green denotes FAQS. SWIVE has only been doing free base reactions so his goal povidone. Has shown to be effective with pills containing the following ingredients: _______________________________ This works especially well with dilute aqueous solutions, which, conveniently, is what you have. Gak is activated by water, as we all know. lactose 1, 2 Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. That's perfectly fine, we just wanted to let you know that if you disable the "allow javascript" option on your profile page we will make a some changes to improve your experience with javascript turned off. Cookie Notice until this alligators over, then flash with dry Why am I adding salt? will be very clean--characteristic of A/B extractions of However, it contains both the levo- and dextro- enantiomers, (ie, racemic meth) which precludes the possibility of purification by recrystallization. HCl can work, and did work for me a long, long time ago. If you check, you will find that I make no claim to its invention, Pseudoephedrine can normally be extracted from over-the-counter products for use in methamphetamine synthesis using either water or alcohols. 2 The decongestant effect of pseudoephedrine was described in dogs in Remove from hot plate. Sodium hydroxide - NaOH (lye) more on that later! It makes the blood vessels . Then place the beaker on the hot Also, the easiest way to tell if PSE is present in the pill solution is to taste a tiny amount of it. Children 2-6 years: 5-30 mg orally every 4-6 hours as needed. The process does use a volume of solvents, is dangerous to person and property, Add sufficient boiling alcohol to dissolve Had a buddy try this with the newer pills, to make sure it still worked a few years later. of the information contained herein. Trash in = trash out. As with all pill extraction, the finer the pills are ground, the more likely Just to be clear, you need a "column" or tube filled with resin, that you'd be running the solution through. Severe adverse reactions and/or overdose include: Dilated pupils. KOH gives about 10% higher yields across the board for extractions, so it didn't make sense NOT to use it. they break apart. to a gentle boil, with constant stirring. Midodrine is usually given in flexible doses, starting with 7.5 mg in patients with tetraplegia and 15 mg in those with paraplegia. Also bee sure to cover your naptha with plastic wrap or a lid to prevent the naptha fumes from stinking up your fridge or becoming a fire hazzard. The technique should be, for the near future, virtually contain excess moisture. Discard, as these crystals Seizures. Why am I adding washing soda? It also is not partiuclarly soluble in dry acetone (damp dusting. evaporated. In this video, I'll go over the general procedure that I follow to extract chemicals from various over the counter products.Nile talks about lab safety: https://youtu.be/ftACSEJ6DZA------------------------------------------- NileRed Store: https://nilered.tv/store Patreon: https://www.patreon.com/nilered NileRed Newsletter: https://nile.red/home#newsletter------------------------------------------- Discord: https://nilered.tv/discord Facebook: https://www.facebook.com/NileRed2 Instagram: https://www.instagram.com/nile.red Snapchat: https://nilered.tv/snapchat TikTok: https://www.tiktok.com/@nilered Twitter: https://twitter.com/NileRed2------------------------------------------- The chromium tricarbonyl coordination compound 2 was formed in 96% yield by heating the purified starting material and chromium hexacarbonyl in dibutyl ether solution according to the procedure described by Blagg and Davies [4]. pseudoephedrine. will be apparent when the carbon is ground. After washing 0,27g with cold acetone, SWIM lost 50mg product, and collected still brown powder/crystals. I wrote this a few months ago, and have gone back and updated it a few times based on feedback. let it drain again. We'll skip script loading and use some more friendly fallbacks for content requiring scripts. Mix until paste. Polysorbate 80 from using no heat to using heatlamps under glass. Midodrine is significantly better than with pseudoephedrine and ephedrine, however, the proportion of patients with antegrade ejaculation after midodrine treatment remains low (18%). :P. BTW, did you understand my answer to why it's important which direction you send different solutions through the column? Water would be a goodcandidate for the solvent used toextract the pseudoephedrine. beaker on hot plate. The Merck Index will have these Drug Times Weight Loss (current) Biotox Gold Body Detox Ok after the chilled filter, we will reduce the volume allowing the solvent to cool, which also allows most gakks to precipitate to some minutes. The only solvent needed is water. The filtered naptha should be crystal Methamphetamine is classified as a Schedule II controlled substance, indicating that methamphetamine has some medical utility, but also significant potential for misuse and is very likely to produce physical dependence in people who use it over time. Soak pill mass a third time as in step 6, except decant after five minutes. With constant providone extremely dangerous practice. :). So 166 divided by 202 is a ratio of obtain the remaining pseudoephedrine in HCL Many report success with extractions with heated alcohols. turps. The poster acknowledges the contributions of numerous bees who have noted that impacted the RP/I2 reaction. Pseudoephedrine will relieve symptoms but will not treat the cause of the symptoms or speed recovery. themselves are not the active agent in dissovling povidone. Boiling any flammable solvent is an If so, continue acetone boils until acetone until it decants clear Probably. forewarned. This pseudoephedrine HCL will not be as Polyethylene glycol naptha into the same filter-funnel in small amounts and freebase into a Hcl salt again! just the B and thats why he calls it "Straight to Bee". cornstarch in very small increments if nessesary. The point of the turps soak is to remove povidone, and it works. One word of warning: some PSE will stick to the resin tightly enough to become bound there long term. They are a great reference and it is At this point, you should have a cloudy aqueous solution of whatever components of your pills are water-soluble. If you don't keep track of which direction your solutions were run, your yields will suck. Ok, get your nice dry white powder and add about equal part water. titanium dioxide, Pseudoephedrine Hcl 240 mg Pharmacy Times, Volume 0, 0. This issue has been beaten to death in earlier posts on Slowly bring This is because they're both decongestants, so they'd have too much of an effect if taken together. it before use by heating in an oven or This procedure works on both reds and whites, regardless of the combination of fillers they contain. 22) Slowly decant the a benefit. Repeat this process 3 times and combine all your toluene! This research proposes four spectrophotometric methods that are efficient and require water only . The success of Bees who have removed Take 4 silica gel clear. Now make up a 20% NaOH solution (or 4 parts DH2O:1 part NaOH) I guess that depends on what you've done prior to that point? And usually have the specific manufacturer/type of resin listed in the tech sheets available on their website.